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Zolpidem is a hypnotic from the group of imidazopyridines. Ambien shortens the time of falling asleep, reduces the number of nocturnal awakenings, increases the total duration of sleep and improves its quality. Lengthens the II stage of sleep and the stage of deep sleep (III and IV). Does not cause drowsiness during the day. If you wanted to buy ambien online without prescription at the lowest price just visit our online pharmacy

Information

Zolpidem is a selective agonist of the subclass of omega-benzodiazepine receptors. Has a sedative effect, when used in normal doses does not have anxiolytic, central muscle relaxant and anticonvulsant action. Excites benzodiazepine receptors (omega) in the alpha subunit of GABA-receptor complexes located in the region of the IV plate of sensory-motor cortical zones, reticular parts of the black substance, visual throats of the ventral thalamic complex, bridge, pallid sphere, etc. Interaction with omega receptors leads to the discovery of neuronal ionoform channels for chloride ions.

Indication

Sleep disorders: difficulty falling asleep, early and night awakenings

Contraindications

Acute and / or severe respiratory failure, severe acute or chronic liver failure, nocturnal apnea (including presumed), due to the presence of lactose in the composition: hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome; pregnancy; lactation period; children's age (up to 18 years); increased sensitivity to zolpidem or other component of the drug.

With caution: severe myasthenia gravis, respiratory failure, mild to moderate hepatic insufficiency, depression, alcoholism, drug addiction and other addictions.

You should not buy ambien without prescription if you have any of the contraindications listed above

Method of application and dosage

Inside (immediately before bed) in a single dose of 10 mg.

In elderly or debilitated patients, if liver function is impaired, treatment is started with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose may be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, in case of a situational one - 2-3 weeks.

Very short periods of treatment do not require the gradual withdrawal of the drug. In the case of long-term use of the drug to reduce the possibility of development of ricochet insomnia, the abolition of zolpidem should be carried out gradually (first a decrease in the daily dose and then the withdrawal of the drug).

Consult your physician about the individual dosage before you decide to buy ambien online.

Side effects

From the nervous system: often - drowsiness, a feeling of intoxication, headache, dizziness, increased insomnia, anterograde amnesia (the effects of amnesia can be associated with behavioral reactions), the risk of developing which increases in proportion to the dose, hallucinations, agitation, nightmares; infrequently - confusion, irritability; frequency is unknown - impairment of consciousness, dysphoria, aggressiveness, visual and auditory hallucinations, increased excitability, behavioral reactions, somnambulism, drug dependence (can develop even when therapeutic doses are used), withdrawal of drug - withdrawal syndrome or ricochet insomnia, decreased libido, gait disturbance , ataxia, falls (mainly in elderly patients), drug addiction (reduction of sedative and hypnotic effects when applied for several weeks). Most side effects from the psyche are paradoxical reactions.

From the digestive system: often - diarrhea, nausea, vomiting, abdominal pain; frequency unknown - increased activity of hepatic enzymes.

From the musculoskeletal system: the frequency is unknown - muscle weakness.

On the part of the skin: the frequency is unknown - rash, itching, urticaria, increased sweating.

Allergic reactions: the frequency is unknown - angioedema.

Other: often - a feeling of fatigue; infrequently it is diplopia.

Interactions

  • Alcohol enhances the sedative effect of zolpidem, joint use is not recommended.
  • Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases;
  • buprenorphine - risk of respiratory depression;
  • ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect;
  • itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem.
  • Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.

Overdose

Symptoms: impaired consciousness (from confusion and inhibition to coma), ataxia, lowering blood pressure, respiratory depression.

Treatment: induction of vomiting within 1 hour after an overdose, activated charcoal, if after an overdose more than 1 hour has passed (with the consciousness stored-inside, with the unconscious - through the probe), gastric lavage, symptomatic therapy. As an antidote, flumazenil (a benzodiazepine receptor antagonist) is recommended, but it should be remembered that antagonism with benzodiazepine receptors can lead to seizures, especially in patients with epilepsy. Dialysis is ineffective.


How Does AmbienWork?



Ambien works by activating the neurotransmitter GABA and binding it to the GABA receptors in the same location as the benzodiazepines such as Xanax and Valium.


The extra GABA activity triggered by the drug inhibits the neuron activity that is associated with insomnia. In other words, it slows down the brain.


Ambien is extremely effective at initiating sleep, usually working within 20 minutes. It does not, however, have an effect on sustaining sleep unless it is taken in the controlled release form.

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